| Jeff Adams (OT) '12 |
Dallas Cowboys, 2012; Cincinnati Bengals, 2012; Tennessee Titans, 2013; Houston Texans, 2014-16; New York Jets, 2017 |
| Mal Bleecker (OL) '30 |
Brooklyn Dodgers, 1930 |
| Jack Boyle (E) |
Chicago Bears, 1926 |
| Steve Cargile (DB) '04 |
Dallas Cowboys, 2004; Tampa Bay Buccaneers, 2006; Denver Broncos, 2006-07; Cleveland Browns, 2008; New York Giants, 2009; Tampa Bay Buccaneers, 2009 |
| John Chirico (RB) '87 |
New York Jets, 1987 |
| Jordan Colbert (DB) '22 |
Miami Dolphins, 2024-Present |
| Marty Domres (QB) '69 |
San Diego Chargers, 1969-71; Baltimore Colts, 1972-75; San Francisco 49ers, 1976; New York Jets, 1977 |
| Wade Fletcher (TE) '05 |
New York Giants, 2006 |
| Bill Garnjost (OL) '21 |
Evansville Crimson Giants, 1921 |
| Bruce Gehrke (RB) '48 |
New York Giants, 1948 |
| Paul Governali (QB) '43 |
Boston Yanks, 1946-47; New York Giants, 1947-48 |
| Ralph Hewitt (RB) '32 |
New York Giants, 1932 |
| Craig Hormann (QB) '08 |
Cleveland Browns, 2008 |
| Lord Hyeamang (DL) '18 |
New York Jets, 2018; Seattle Seahawks, 2018; Los Angeles Rams, 2018 |
| Doug Jackson (RB) '76 |
Dallas Cowboys, 1977-78; New York Giants, 1978-79 |
| Leon Johnson (E) |
Orange Tornadoes, 1929 |
| Tom Kerrigan (OL) '25 |
Orange Tornadoes, 1929; Newark Tornadoes, 1930 |
| George Kisiday (E) '48 |
Buffalo Bills, 1948 |
| Walt Koppisch (OB) |
Buffalo Bills, 1925; New York Giants, 1926 |
| Lou Kusserow (RB) '49 |
Detroit Lions, 1949; New York Yankees, 1949; New York Yanks, 1950 |
| Sid Luckman (QB) '39 |
Chicago Bears, 1939-51 |
| Herb Maack (OT) '42 |
Brooklyn Dodgers, 1946 |
| Josh Martin (DE) '13 |
Kansas City Chiefs, 2013-14; Tampa Bay Buccaneers, 2015; Indianapolis Colts, 2015; New York Jets, 2015-19; New Orleans Saints, 2019 |
| Dante Miller (RB) '22 |
New York Giants, 2024-Present |
| Cliff Montgomery (QB) '34 |
Brooklyn Dodgers, 1934 |
| Cameron Nizialek (P) '17 |
Baltimore Ravens, 2019; Atlanta Falcons, 2020-21; Pittsburgh Steelers, 2022 |
| Kendall Pace (DL) '17 |
Pittsburgh Steelers/Washington, 2017 |
| George Pease (QB/HB) '26 |
New York Yankees, 1926; Orange Tornadoes, 1929 |
| Jeff Otis (QB) '05 |
Arizona Cardinals, 2006; Oakland Raiders, 2007-09; Kansas City Chiefs, 2007; St. Louis Rams, 2009 |
| Michael Quarshie (DT) '05 |
Oakland Raiders, 2006 |
| Johnathan Reese (RB) '02 |
New York Jets, 2003-04; Denver Broncos, 2004; Tampa Bay Buccaneers, 2005 |
| Harry Robb (HB/QB) '21 |
Canton Bulldogs, 1921-26 |
| Archie Roberts (QB) '65 |
New York Jets, 1966; Miami Dolphins, 1967 |
| Steve Schimititisch (OL) |
New York Yankees, 1926 |
| Johnny Siegal (WR) '39 |
Chicago Bears, 1939-43 |
| George Starke (TE) '71 |
Washington, 1972-84 |
| Bruce Stephens (RB/WR) '78 |
New York Jets, 1978 |
| Bill Swiacki (WR) '48 |
New York Giants, 1948-50; Detroit Lions, 1951-52 |
| Dan Upperco (WR) '85 |
Los Angeles Raiders, 1985 |
| Ray Wagner (WR/HB) '26 |
Orange Tornadoes, 1929; Newark Tornadoes, 1930; Brooklyn Dodgers, 1931 |
| Marcellus Wiley (DE) '97 |
Buffalo Bills, 1997-2000; San Diego Chargers, 2001-03; Dallas Cowboys, 2004; Jacksonville Jaguars, 2005-06 |
| Rory Wilfork (LB) '97 |
Arizona Cardinals, 1997 |
| John Witkowski (QB) '84 |
Detroit Lions, 1984; Houston Oilers, 1986-87; Detroit Lions, 1988 |
| Ventan Yablonski (FB) '48 |
Chicago Cardinals, 1948-51 |
| Jerry Zawadzkas (TE) '67 |
Detroit Lions, 1967 |
