Penn hit a blistering .312 for the three-game match, highlighted by a .400 hitting percentage in game two, en route to a 3-0 win at the Palestra.
The Lions fell to 5-9, 0-5 Ivy League, while Penn improved to 7-8, 2-2 Ivy League.
The Liosn couldn't string together a tough enough run to get back into the game, as Penn made just 13 errors in all three games. Amalia Viti led the Lions with seven kills, and Gabi D'Addario added four kills and one error.
The Lions return to action tomorrow when they travel to Princeton for a 4 p.m. game.